體驗區
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| 篇名 |
制約恐懼對老鼠痛覺過敏反應的影響
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| 並列篇名 |
EFFECT OF CONDITIONED FEAR ON RESPONSIVENESS TO YPERALGESIA IN RATS
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| 作者 |
金樹人
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| 中文摘要 |
本实验研究之目的在于验证制约恐惧（conditioned fear）对老鼠痛觉过敏（hyperalgesia）反应的影响。过去的研究发现，老鼠在制约恐惧情境下的痛觉反应并不一致，有趋向两极的痛觉反应倾向：其一是「痛觉丧失」（analgesia），其二是「痛觉过敏」。本实验研究中以老鼠尾部反弹反射（tai-flick rdflexes）的潜伏期（latencies）设定为测量痛觉反应之指针，假设经由制约恐惧的引发，会产生心因性的痛觉过敏反应，而非痛觉丧失。实验分成三个阶段进行：持握（handing）、恐惧制约（fear congitionong）与测试处理（testing）。持握阶段系将老鼠把持于手掌，期使熟悉人手之持握。在恐惧制约阶段，实验组（N＝11）与控制组（N＝11）均接受等量的电击处置。尾部反弹反射之实验处理阶段，实验组接受制约恐惧的实验处理，控制组则无。结果显示实验组较控制组有较短的尾部反弹潜伏期（P＜0.1），显示出痛觉过敏的反应。对于本研究与其它实验在研究方法、过程与结果的差异，均予检验与讨论。
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| 英文摘要 |
A number of recent research studies have suggested that the response of pain to electric shock can be conditioned. However, mixed results stemmed from these studies producing either conditioned analgesia (insensitivity to pain) or hyperalgesia when triggered by various conditioned stimuli. The present study hypothesized that psychogenic hyperalgesia can be triggered by conditioned fear as measured by tailflick latencies. In the present experiment, rats (N=22) were exposed to shock an equal number of times in conditioning sessions. Separate groups were then tested either with or without a conditioned fear stimulus (CS) in a tail-flick test. The hypothesis was supported. It was found that a fear CS appeared to produce significantly (p<.01) decreased tail -flick latencies indicating a hyperalgesic response. The nature of the tail-flick reflex and the procedures used by studies producing the various findings were discussed.
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| 頁次 |
041-062
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| 關鍵詞 |
TSSCI
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| 卷期 |
32:1
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| 日期 |
1987
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| 刊名 |
教育科學研究期刊
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| 出版單位 |
國立臺灣師範大學
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